Genetic circuit design automation
It has been shown that cells can be programmed using synthetic genetic circuits composed of regulators organized to generate a desired operation. In an effort to accelerate genetic circuit design, we applied principles from EDA to enable increased circuit complexity and to simplify the incorporation of synthetic gene regulation into genetic engineering projects. We used the hardware description language Verilog to enable a user to describe a circuit function. Cello uses this information to automatically design a DNA sequence encoding the desired circuit. This is done via a set of algorithms that parse the Verilog text, create the circuit diagram, assign gates, balance constraints to build the DNA, and simulate performance.
RESULTSCello designs circuits by drawing upon a library of Boolean logic gates. Cello was applied to the design of 60 circuits for Escherichia coli, where the circuit function was specified using Verilog code and transformed to a DNA sequence. Algorithms build a circuit diagram, assign and connect gates, and simulate performance. Reliable circuit design requires the insulation of gates from genetic context, so that they function identically when used in different circuits. We used Cello to design 60 circuits for Escherichia coli, for which each DNA sequence was built as predicted by the software with no additional tuning.
Of these, 45 circuits performed correctly in every output state, and across all circuits 92% of the output states functioned as predicted. Design automation simplifies the incorporation of genetic circuits into biotechnology projects that require decision-making, control, sensing, or spatial organization.
ETS Research: Automated Scoring of Speech
ETS’s research agenda related to automated scoring of speech includes the development of more extensive NLP features to represent pragmatic competencies and the discourse structure of spoken responses. Below are some recent or significant publications that our researchers have authored on the subject of automated scoring of speech. The article presents a study of new measures of syntactic complexity, which automated scoring systems can use when assessing-second language spontaneous speech. The authors compared different ways of selecting features in automated scoring systems that evaluate spoken or written responses in language assessments. The report summarizes research and development efforts focusing on scoring models for automatically scoring spoken-item responses, for a pilot administration of a test for nonnative English teachers or teacher candidates.
The author shows that machine-generated scores can effectively approximate the scores of human raters for use in model-building for automated speech assessment. Prompt-based content scoring for automated spoken language assessment. In this paper, researchers compare two alternative scoring methods for an automated scoring system for speech. Researchers explore content features for automated speech scoring in this paper about automated scoring of unrestricted spontaneous speech. In this paper, researchers present a method that measures English language learners’ syntactic competence for the automated speech scoring systems.
A system for automated scoring of nonnative speakers’ spoken English proficiency. View more research publications related to automated scoring of speech.
Automation news, analysis and opinion
Editor-at-large, 4/25/2018 Service providers of all stripes are moving rapidly to automate their networks, says one global study, but perhaps surprisingly, security is one of their major … By Paul Rainford. Assistant Editor, Europe, 4/25/2018 Also in today’s EMEA regional roundup: Apple starts paying Irish back-taxes; Nokia gets edgy; Atos hooks up with Google for AI; Elisa trumpets NB-IoT network. Editor, 4/25/2018 Telstra’s Jim Fagan explains how service providers can apply lessons learned about automation in the cloud to delivering more automation in their networks. Despite today’s upbeat news that Verizon beat …
By Iain Morris. News Editor, 4/24/2018 Telenor’s first-quarter numbers should have been a treat for any investor. Editor-at-large, 4/23/2018 Telecom network operators have a love-hate relationship with OpenStack. On the one hand, it is ubiquitously deployed as an open-source cloud platform, and the default … By Iain Morris.
News Editor, 4/23/2018 Sometimes it’s hard to be Gavin, Tammy Wynette might have sung if only it had scanned. A recent report from Microsoft shows that the number of scams using tech support … Alan Zeichick, Principal Analyst, Camden Associates, 4/25/2018. You can’t trust anything – not the cloud, not hardware, not industrial control … Broadband World News.
Light Reading is thrilled to announce the finalists for this year’s Leading … Iain Morris , News Editor , 3/14/2018. Network management vendor revamps its strategy to promote itself as a telco cloud … Ray Le Maistre , Editor-in-Chief , 2/7/2018.
Content migration: options and strategies
This article explores a number of options for the migrating content, and provides some practical suggestions that should help it to go smoothly. Chief amongst these are content problems: content is out of date, poorly structured, not written well, incomplete or inconsistent. Once the new site is live, the pressure to clean up the content evaporates, and content updates return to their usual slow pace. The more content that can be removed, simplified or rewritten early in the project, the easier the eventual content migration will be. Clear standards should be outlined for content on the new site, and these should be communicated to all content owners.
One strategy is to list all the orphaned content publicly, stating that all the content will be deleted rather than migrated, unless an owner can be found. Outsourcing in this way has the obvious benefit of bringing greater resources to bear on the content migration, without burdening the centralised team or decentralised content owners. It won’t be possible for the central team to do all the content migration, and the distributed content owners will need to be co-opted into the process. While the content owners are well placed to review the relevance of the content, they are typically not professional writers. It can be difficult to manage the migration of content, while new content is being created and pages are still being updated.
The quality of the content is a key element of this, and this won’t be delivered if the content migration is rushed or poorly managed. While content migration can sometimes be automated, a manual cut-and-paste migration effort is much more likely.